Symbol
Name
ID

Cdk5rap2
CDK5 regulatory subunit associated protein 2
MGI:2384875

Phenotype annotations related to nervous system

Darker colors indicate more annotations

Human Phenotypes	Microcephaly	Primary microcephaly	Simplified gyral pattern	Small cerebral cortex	Partial agenesis of the corpus callosum	Cognitive impairment	Intellectual disability	Intellectual disability, moderate	Global developmental delay	Mild global developmental delay
Disease(s) Associated with CDK5RAP2	Microcephaly	Primary microcephaly	Simplified gyral pattern	Small cerebral cortex	Partial agenesis of the corpus callosum	Cognitive impairment	Intellectual disability	Intellectual disability, moderate	Global developmental delay	Mild global developmental delay
primary autosomal recessive microcephaly 3
Seckel syndrome

Mouse Phenotypes

increased neuron apoptosis

abnormal neuron proliferation

abnormal forebrain development

decreased brain size

enlarged brain ventricles

small hippocampus

abnormal cerebral cortex morphology

loss of cortex neurons

thin cerebral cortex

small olfactory bulb

abnormal embryonic/fetal subventricular zone morphology

Availability

Mouse Genotype

Cdk5rap2^an/Cdk5rap2^an

Contributing Projects: Mouse Genome Database (MGD), Gene Expression Database (GXD), Mouse Models of Human Cancer database (MMHCdb) (formerly Mouse Tumor Biology (MTB)), Gene Ontology (GO)
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